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The function of hypochlorous acid (HOCl)

May 5, 2023

Latest company news about The function of hypochlorous acid (HOCl)

1 Bactericidal performance - the most basic and main function of hypochlorous acid

 

Sterilization is the main function of hypochlorous acid. The surface of the cell membrane of microorganisms is negatively charged, so hypochlorite (ClO-, also negatively charged) cannot easily enter the cell interior, while hypochlorous acid (HClO) is neutral Small molecules that can penetrate the cell membrane, enter the interior of the cell, and react with the DNA and mitochondria inside it, causing it to die. Needless to say, many other functions of hypochlorous acid are derived from this function.

 

2 Freshness preservation performance - extension of hypochlorous acid sterilization function

Electrolyzed hypochlorous acid water belongs to the soaking antiseptic preservative, which achieves the purpose of antiseptic and fresh preservation by soaking, spraying, etc. The hypochlorous acid water can kill or control the pathogenic microorganisms on the surface or inside of fruits and vegetables, and can adjust the growth rate of fruits and vegetables after harvesting. respiratory metabolism.

Studies have shown that slightly acidic hypochlorous acid water not only has a fresh-keeping effect on fruits and vegetables, but also has a good fresh-keeping effect on livestock and poultry products and aquatic products, and can also ensure the stability of their quality indicators.

 

3 Deodorizing performance - hypochlorous acid can decompose a variety of odor molecules

Hypochlorous acid water has an excellent removal effect on dimethyl disulfide (smell like rotten cabbage), ammonia (smell like urine), propionic acid (pungent smell with sweet and sour and burnt) Hydrogen (smell like rotten eggs), trimethylamine (smell like rotten fish), n-butyric acid (sweat odor), n-valeric acid (smell of wet socks) also performed well.

 

4 Formaldehyde removal performance - hypochlorous acid oxidation can decompose formaldehyde

Hypochlorous acid water can also be used for indoor formaldehyde removal. Due to its strong oxidizing properties, hypochlorous acid water has a certain removal effect on formaldehyde in the air through spraying, and its reaction is as follows:

 

HCHO+HClO=HCOOH+HCl

 

The report shows that when hypochlorous acid is used for atomization for 10 minutes, the formaldehyde concentration in the 0.8m³ incubator drops from 0.95ppm to 0.21ppm, with a drop rate of 77.9%. When it reaches near the critical value of the formaldehyde concentration specification, as time goes on, the formaldehyde concentration drops slowly, and it takes about 6 minutes to drop from 0.11ppm to 0.07ppm.

 

5 Promotes wound healing - an ideal wound care agent

Wound healing is a physiological process involving the coordination of various cytokines and growth factors, involving cell biology such as cell movement, adhesion, proliferation and differentiation.

 

The stable HOCl solution acts as an ideal wound care solution for its powerful and rapid killing effect on different types of microorganisms, biofilms and bacteria in biofilms. Second, it has dose-dependent beneficial effects on fibroblast and keratinocyte migration. At the same time, studies have shown that 0.01% hypochlorous acid solution can increase the number of new capillaries in rat wound granulation tissue and increase the level of fibroblasts in rat wound granulation tissue, which can provide a basis for clinical use. These characteristics make HOCl solution an ideal wound care agent.

 

6 Antipruritic Properties – Hypochlorous Acid Reduces Itching and Inflammation in the Body

 

North Carolina State University T. Fukuyama study found that treatment with HOCl hydrogel prevents lesion development and scratching. When administered after fully developed lesions, HOCl reduced lesions and scratching behavior to a similar extent as the positive control, 0.1% betamethasone dipropionate ointment. The therapeutic effect of HOCl was demonstrated by reducing the secretion of inflammatory cytokines in the affected skin tissues of NC/Nga mice. Furthermore, HOCl significantly decreased IL-12 production in mBMDCs. Attenuation of scratching behavior was demonstrated by impaired responses to several pruritants excised from dorsal root ganglion neurons of NC/Nga mice at the end of the study. These data suggest that HOCl directly reduces sensory responses, thereby significantly reducing itching and inflammation in vivo.

 

7 Pesticide substitution performance - hypochlorous acid can prevent crop diseases

 

Slightly acidic hypochlorous acid water replaces or partially replaces chemical pesticides to prevent and control crop diseases, which not only reduces the use of chemical pesticides, but also has great advantages in terms of safety in use, convenience in operation and economy.

 

The research group of Professor Li Lite from China Agricultural University took the lead in conducting research on electrolyzed water in crop disease control in my country. From 2003 to 2009, the research group showed that acidic electrolyzed hypochlorous acid water is effective against grape anthracnose, cucumber powdery mildew, wheat Diseases such as stripe rust and tomato leaf mold have good control effects.

 

In 2003, the Ministry of Agriculture, Forestry and Fisheries of Japan identified hypochlorous acid water (obtained only by electrolysis of hydrochloric acid or potassium chloride aqueous solution) as a specific pesticide.

 

8 Growth-Promoting Properties – Hypochlorous Acid Promotes Plant Growth

Irrigation of plants with electrolyzed hypochlorous acid water also shows a significant growth-promoting effect. On the one hand, this effect is due to the suppression of soil-borne diseases, and on the other hand, it is due to the activation of many mineral elements in the soil by electrolyzed hypochlorous acid water. , thereby promoting the growth and metabolism of the plant; the treated water has smaller molecular groups, which is more conducive to the water metabolism and achieves the purpose of promoting growth. Its growth-promoting effect is multifaceted. However, the growth-promoting effect of hypochlorous acid water on plants is not yet clear, and there may be differences among different crops, which need to be further studied.

 

9 Removal of Aflatoxin - Oxidative Ability of Hypochlorous Acid

 

Aflatoxin is produced by Aspergillus flavus and Aspergillus parasiticus. Among the aflatoxins, aflatoxin B1 (AFB1) is the most toxic and carcinogenic.

 

AFB1 has a wide distribution range, and AFB1 contamination has been detected in grain, oil, animal and plant foods, such as peanuts, corn, rice, wheat, beans, nuts, meat, milk and dairy products, and aquatic products. Among them, peanut and corn are the most polluted. All countries attach great importance to the problems of Aspergillus flavus infection and toxin B1 contamination in agricultural products, food and feed. In 1993, AFB1 was designated as a Class 1 carcinogen by the Cancer Research Institute of the World Health Organization, and it is the most toxic natural poison currently known.

 

Xiong Ke et al. used acidic electrolytic hypochlorous acid water to remove AFB1, and identified and evaluated the safety of the generated products. To reveal the mechanism of AFB1 scavenging by acid electrolysis of hypochlorous acid water. The test results show that: after high-resolution mass spectrometry analysis, the relative molecular mass of the main product generated by the removal of AFB1 by acidic hypochlorous acid water is 364, and the chemical formula is C17H13ClO7. Combined with NMR analysis, it was confirmed that the unknown product was 8-chloro-9-hydroxy-Aflatoxin B1 (8-Cl-9-OH-AFB1). It is an organic molecule with amphiphilic properties. The safety research results of the product show that the product has no mutagenicity, its IC50 value of the half lethal dose concentration is about 150 mmol/L, and it has no toxic effect on cells. The application safety of AFB1 removal by acidic electrolytic hypochlorous acid water is clarified, and a safe, effective and promising new way to remove AFB1 pollution is provided.

 

10 Mite removal performance - hypochlorous acid can remove mites

Mites are microscopic pests that are not easily seen by the naked eye, and there are many types. So far, more than 40 species of mites have been found living in the living room, of which more than ten are related to human health. The most common ones are dust mites, acaroid mites, demodex mites, and scabies mites. The survey shows that about 97% of adults are infected with mites, of which dust mites are the main ones. Dust mite carcasses, secretions, and excreta are allergens that can cause disease. They breed on carpets, sofas, plush toys, bedding, cushions, mattresses, and pillow cores. They feed on human sweat, secretions, and exfoliated dander, and their reproduction speed is extremely fast.

1 Bactericidal performance - the most basic and main function of hypochlorous acid

 

Sterilization is the main function of hypochlorous acid. The surface of the cell membrane of microorganisms is negatively charged, so hypochlorite (ClO-, also negatively charged) cannot easily enter the cell interior, while hypochlorous acid (HClO) is neutral Small molecules that can penetrate the cell membrane, enter the interior of the cell, and react with the DNA and mitochondria inside it, causing it to die. Needless to say, many other functions of hypochlorous acid are derived from this function.

 

2 Freshness preservation performance - extension of hypochlorous acid sterilization function

Electrolyzed hypochlorous acid water belongs to the soaking antiseptic preservative, which achieves the purpose of antiseptic and fresh preservation by soaking, spraying, etc. The hypochlorous acid water can kill or control the pathogenic microorganisms on the surface or inside of fruits and vegetables, and can adjust the growth rate of fruits and vegetables after harvesting. respiratory metabolism.

Studies have shown that slightly acidic hypochlorous acid water not only has a fresh-keeping effect on fruits and vegetables, but also has a good fresh-keeping effect on livestock and poultry products and aquatic products, and can also ensure the stability of their quality indicators.

 

3 Deodorizing performance - hypochlorous acid can decompose a variety of odor molecules

Hypochlorous acid water has an excellent removal effect on dimethyl disulfide (smell like rotten cabbage), ammonia (smell like urine), propionic acid (pungent smell with sweet and sour and burnt) Hydrogen (smell like rotten eggs), trimethylamine (smell like rotten fish), n-butyric acid (sweat odor), n-valeric acid (smell of wet socks) also performed well.

 

4 Formaldehyde removal performance - hypochlorous acid oxidation can decompose formaldehyde

Hypochlorous acid water can also be used for indoor formaldehyde removal. Due to its strong oxidizing properties, hypochlorous acid water has a certain removal effect on formaldehyde in the air through spraying, and its reaction is as follows:

 

HCHO+HClO=HCOOH+HCl

 

The report shows that when hypochlorous acid is used for atomization for 10 minutes, the formaldehyde concentration in the 0.8m³ incubator drops from 0.95ppm to 0.21ppm, with a drop rate of 77.9%. When it reaches near the critical value of the formaldehyde concentration specification, as time goes on, the formaldehyde concentration drops slowly, and it takes about 6 minutes to drop from 0.11ppm to 0.07ppm.

 

5 Promotes wound healing - an ideal wound care agent

Wound healing is a physiological process involving the coordination of various cytokines and growth factors, involving cell biology such as cell movement, adhesion, proliferation and differentiation.

 

The stable HOCl solution acts as an ideal wound care solution for its powerful and rapid killing effect on different types of microorganisms, biofilms and bacteria in biofilms. Second, it has dose-dependent beneficial effects on fibroblast and keratinocyte migration. At the same time, studies have shown that 0.01% hypochlorous acid solution can increase the number of new capillaries in rat wound granulation tissue and increase the level of fibroblasts in rat wound granulation tissue, which can provide a basis for clinical use. These characteristics make HOCl solution an ideal wound care agent.

 

6 Antipruritic Properties – Hypochlorous Acid Reduces Itching and Inflammation in the Body

 

North Carolina State University T. Fukuyama study found that treatment with HOCl hydrogel prevents lesion development and scratching. When administered after fully developed lesions, HOCl reduced lesions and scratching behavior to a similar extent as the positive control, 0.1% betamethasone dipropionate ointment. The therapeutic effect of HOCl was demonstrated by reducing the secretion of inflammatory cytokines in the affected skin tissues of NC/Nga mice. Furthermore, HOCl significantly decreased IL-12 production in mBMDCs. Attenuation of scratching behavior was demonstrated by impaired responses to several pruritants excised from dorsal root ganglion neurons of NC/Nga mice at the end of the study. These data suggest that HOCl directly reduces sensory responses, thereby significantly reducing itching and inflammation in vivo.

 

7 Pesticide substitution performance - hypochlorous acid can prevent crop diseases

 

Slightly acidic hypochlorous acid water replaces or partially replaces chemical pesticides to prevent and control crop diseases, which not only reduces the use of chemical pesticides, but also has great advantages in terms of safety in use, convenience in operation and economy.

 

The research group of Professor Li Lite from China Agricultural University took the lead in conducting research on electrolyzed water in crop disease control in my country. From 2003 to 2009, the research group showed that acidic electrolyzed hypochlorous acid water is effective against grape anthracnose, cucumber powdery mildew, wheat Diseases such as stripe rust and tomato leaf mold have good control effects.

 

In 2003, the Ministry of Agriculture, Forestry and Fisheries of Japan identified hypochlorous acid water (obtained only by electrolysis of hydrochloric acid or potassium chloride aqueous solution) as a specific pesticide.

 

8 Growth-Promoting Properties – Hypochlorous Acid Promotes Plant Growth

Irrigation of plants with electrolyzed hypochlorous acid water also shows a significant growth-promoting effect. On the one hand, this effect is due to the suppression of soil-borne diseases, and on the other hand, it is due to the activation of many mineral elements in the soil by electrolyzed hypochlorous acid water. , thereby promoting the growth and metabolism of the plant; the treated water has smaller molecular groups, which is more conducive to the water metabolism and achieves the purpose of promoting growth. Its growth-promoting effect is multifaceted. However, the growth-promoting effect of hypochlorous acid water on plants is not yet clear, and there may be differences among different crops, which need to be further studied.

 

9 Removal of Aflatoxin - Oxidative Ability of Hypochlorous Acid

 

Aflatoxin is produced by Aspergillus flavus and Aspergillus parasiticus. Among the aflatoxins, aflatoxin B1 (AFB1) is the most toxic and carcinogenic.

 

AFB1 has a wide distribution range, and AFB1 contamination has been detected in grain, oil, animal and plant foods, such as peanuts, corn, rice, wheat, beans, nuts, meat, milk and dairy products, and aquatic products. Among them, peanut and corn are the most polluted. All countries attach great importance to the problems of Aspergillus flavus infection and toxin B1 contamination in agricultural products, food and feed. In 1993, AFB1 was designated as a Class 1 carcinogen by the Cancer Research Institute of the World Health Organization, and it is the most toxic natural poison currently known.

 

Xiong Ke et al. used acidic electrolytic hypochlorous acid water to remove AFB1, and identified and evaluated the safety of the generated products. To reveal the mechanism of AFB1 scavenging by acid electrolysis of hypochlorous acid water. The test results show that: after high-resolution mass spectrometry analysis, the relative molecular mass of the main product generated by the removal of AFB1 by acidic hypochlorous acid water is 364, and the chemical formula is C17H13ClO7. Combined with NMR analysis, it was confirmed that the unknown product was 8-chloro-9-hydroxy-Aflatoxin B1 (8-Cl-9-OH-AFB1). It is an organic molecule with amphiphilic properties. The safety research results of the product show that the product has no mutagenicity, its IC50 value of the half lethal dose concentration is about 150 mmol/L, and it has no toxic effect on cells. The application safety of AFB1 removal by acidic electrolytic hypochlorous acid water is clarified, and a safe, effective and promising new way to remove AFB1 pollution is provided.

 

10 Mite removal performance - hypochlorous acid can remove mites

Mites are microscopic pests that are not easily seen by the naked eye, and there are many types. So far, more than 40 species of mites have been found living in the living room, of which more than ten are related to human health. The most common ones are dust mites, acaroid mites, demodex mites, and scabies mites. The survey shows that about 97% of adults are infected with mites, of which dust mites are the main ones. Dust mite carcasses, secretions, and excreta are allergens that can cause disease. They breed on carpets, sofas, plush toys, bedding, cushions, mattresses, and pillow cores. They feed on human sweat, secretions, and exfoliated dander, and their reproduction speed is extremely fast.

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